Volume 1 Issue 1

Editorial : Therapeutic Perspectives of Alzheimer's Disease

Zhao Zhong Chong*

Alzheimer's disease (AD) is the most common dementia that leads to a progressive deterioration of cognitive function with memory loss. With increasing ageing population in our society, AD influences more and more people in their late life. Although significant advances have been made in the pathological process of AD after its discovery for over a century, the effects targeting the assumed clarified pathogenesis for the treatment of AD are still elusive.

Cite this Article: Chong ZZ. Therapeutic Perspectives of Alzheimer's Disease . Alzheimers Parkinsons Dis Open Access. 2015;1(1): 010-012.

Published: 31 December 2015

Editorial : The Consequence of Noradrenergic Neuronal Loss in the CNS of Alzheimer's Disease

Patricia Szot*

The presence of plaques and neurofibrillary tangles (NFTs) are the hallmark neuropathology associated with Alzheimer's disease (AD); however AD is also characterized neuropathologically by neurodegeneration. My laboratory and many others have shown a substantial loss of noradrenergic cell bodies in postmortem brain tissue of AD subjects in the locus coeruleus (LC), the major source of noradrenergic projections to the whole brain (Marcyniuk et al. 1986; Chan-Palay and Asan, 1989; German et al. 1992; Szot, et al. 2006; McMillan et al. 2011).

Cite this Article: Szot P. The Consequence of Noradrenergic Neuronal Loss in the CNS of Alzheimer's Disease. Alzheimers Parkinsons Dis Open Access. 2015;1(1): 007-009.

Published: 31 December 2015

Editorial : Cytokines in Chronic Neurodegenerative Diseases

Marcella Reale*

There has been an increasing interest in the role of inflammation as a common mechanism of disease in a several medical disorders including cardiovascular and neurodegenerative diseases, diabetes and cancer [1-3]. Indeed, epidemiological studies found that inflammation biomarkers may help to predict the development and progression of these illnesses.

Cite this Article: Reale M. CYTOKINES IN CHRONIC NEURODEGENERATIVE DISEASES. Alzheimers Parkinsons Dis Open Access. 2015;1(1): 004-006.

Published: 31 December 2015

Editorial : Self-Consciousness, key in the Understanding of Neurodegenerative Diseases' Behavioural Troubles

Eva M, ARROYO-ANLLO*, Roger GIL

There is considerable evidence that abnormal behaviour is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer's disease, fronto-temporal dementias. The role of self-consciousness (SC) in behavioural troubles of brain diseases is an emerging neuroscience topic, supported by evidence from studies in the last decade of years. These studies have spurred a growing interest in understanding the troubles of SC in neurodegenerative diseases, as well as the development of psycho-therapeutic approaches that may be able to improve the management of behavioural symptoms of patients and their quality of life.

Cite this Article: ARROYO-ANLLO EM, GIL R. Self-Consciousness, key in the Understanding of Neurodegenerative Diseases' Behavioural Troubles. Alzheimers Parkinsons Dis Open Access. 2015;1(1): 001-003.

Published: 31 December 2015

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