Volume 2 Issue 2
Research Article: In silico Antidiabetic Activity of Linalool Isolated From Coriandrum sativum Linn Fruit
M Padmaa Paarakh*
Background and aim: Diabetes Mellitus [DM] is a metabolic disorder characterized by disturbances in carbohydrate, protein and lipid metabolism and by complications like micro vascular (retinopathy, neuropathy and nephropathy) and macro vascular (heart attack, stroke and peripheral vascular disease) complications. Coriandrum sativum Linn has been claimed to possess antidiabetic properties in Traditional System of Medicine. This study aimed to evaluate molecular interaction of linalool in C.sativum and targeted protein related to Type 2 DM.
Material and Methods: Isolation of Linalool from the methanol extract of fruit of C.sativum was done by column chromatography. Evaluation of hypoglycemic activity through an in silico docking approach with molecular target such as glutamine: fructose- 6-phosphate amidotransferase was performed. Molecular docking study was performed with Autodock docking software.
Results: The docking studies of the ligand linalool with target protein showed that this is a good inhibitor, which docks well related to diabetes mellitus with -2.0297kJ mol-1 Van der waal energy and -5.9265 kJ mol-1 as docking energy. Hence linalool can be considered for developing into a potent anti-diabetic drug.
Conclusion: Management of diabetes is challenge to the medical treatment. This leads to increasing demand for natural products with antidiabetic activity with fewer side effects. This work establishes C.sativum extract as a potential inhibitor for diabetes. Thus enabling a possibility of this plant extract as a new alternative to existing diabetic treatment.
Cite this Article: Padmaa Paarakh M. In Silico Antidiabetic Activity of Linalool Isolated From Coriandrum Sativum Linn Fruit. Int J Cancer Cell Biol Res. 2017; 2(2): 029-033.
Published: 128 September 2017
Authors submit all Proposals and manuscripts via Electronic Form!