Volume 3 Issue 1

Research Article: Protective Effect of Mallow Leaves Extract against Loperamide-induced Oxidative Stress in Rat Jejunum

Mohamed Amine Jabri*, Najla Hajji, Dalanda Wannes, Lamjed Marzouki and Hichem Sebai

Loperamide (LOP) is an antidiarrheal agent that works by slowing gastrointestinal transit and reducing intestinal secretions. The aim of the study is to evaluate the effect of loperamide consumption for five days on the intestinal oxidative balance, as well as the putative protective effect of mallow leaves extract. Animals were divided into one normal control group and five experimental groups. LOP, LOP + the different doses of the extract (100, 200, and 400 mg/ kg, b.w.), and LOP+ yohimbine (2 mg/ kg, b.w. p.i.), used as reference drug. Loperamide (3 mg/ kg, b.w. p.o) was administered twice a day, for 5 days. Treatment with mallow extract or yohimbine protected against the lipid peroxidation, antioxidant enzymes activity depletion, the fall in the thiol group and reduced glutathione level as well as jejunal free iron and H2O2 overload induced by loperamide intoxication. Thereby, Malva sylvestris aqueous extract (MSAE) attenuates the pathogenicity of loperamide.
Keywords: Loperamide; Malva sylvestris; Yohimbine; Lipid peroxidation; Jejunum; Oxidative balance; Thiol group; Free iron

Cite this Article: Jabri MA, Hajji N, Wannes D, Marzouki L, Sebai H. Protective Effect of Mallow Leaves Extract against Loperamide-induced Oxidative Stress in Rat Jejunum. Int J Hepatol Gastroenterol. 2017;3(1): 022-027.

Published: 28 July 2017

Research Article: Endoscopic vs. Medical Therapy for Bleeding Peptic Ulcers with Adherent Clot: a Randomized Comparative Trial

Ajaz A. Telwani, Azhar H. Baba, Mohammed Y. Mujoo, Younis Ashraf and Khalid Rasheed*

Upper gastrointestinal bleeding is the most common and potentially life threatening emergency. Despite great advances in the field of medicine, the optimal management of bleeding peptic ulcer with adherent clot on endoscopy is still controversial. The aim of this study is to compare the combined endoscopic and medical therapy with medical therapy alone for bleeding peptic ulcer with adherent clot (Forrest type IIB). During two-year study period, around 342 patients presented to our tertiary care hospital with acute upper gastrointestinal bleeding. Out of these, 81 patients were noted to have adherent clot (Forrest type IIB) during endoscopy and were included in study. 40 patients received combined endoscopic and medical treatment, whereas 41 patients received medical treatment only. The base line characteristics of patients in two groups were comparable. Primary Outcome being recurrence of bleeding within 7 days of treatment was less in combined therapy group compared to medical therapy group (2.5% vs. 17.1%). This was statistically significant. Secondary outcome like recurrence of bleed in 30 days and need for repeat endoscopy were less in combined group compared to medical therapy group. These were statistically significant as well. Other secondary outcomes like necessity for surgery and mortality were fewer in combined group, but these were not statistically significant. In conclusion combination endoscopic therapy consisting of epinephrine injection, removal of the adherent clot, and treatment of underlying stigmata is more effective than medical therapy alone.
Keywords: Gastrointestinal bleed; Adherent Clot; Endoscopic therapy; Medical therapy

Cite this Article: Telwani AA, Baba AH, Mujoo MY, Ashraf Y, Rasheed K. Endoscopic vs. Medical Therapy for Bleeding Peptic Ulcers with Adherent Clot: a Randomized Comparative Trial. Int J Hepatol Gastroenterol. 2017;3(1): 017-021.

Published: 14 July 2017

Case Report: Can we Diagnose Juvenile Polyposis Syndrome without Genetics? - Case Report and Review of Literature

Virtut Velmishi*, Olta Meta, Gentiana Cekodhima and Paskal Cullufi

Our case report presents a ten-year-old boy who complains abdominal pain and rectal bleeding for more than six months. Other clinical findings were digital hippocratism and failure to thrive. Colonoscopy had shown 12 polyps from anus to cecum whose histology confirmed Juvenile character, non adenomatous and free of dysplasia. Diagnosis of Juvenile Polyposis Syndrome was more probable but a differential diagnosis from other intestinal polyposis especially from hamartomatous syndromes is crucial.

Cite this Article: Velmishi V, Meta O, Cekodhima G, Cullufi P. Can we Diagnose Juvenile Polyposis Syndrome without Genetics? - Case Report and Review of Literature. Int J Hepatol Gastroenterol. 2017;3(1): 013-016.

Published: 04 July 2017

Research Article: Bridging the Gap between Knowledge about Viral Hepatitis Infection (B&C) and their Prevalence among Pregnant Women

Entesar M. Makhlouf, Safaa AA. Khaled* and Madiha M. Tosson

Background & Objective: Worldwide, nearly 350 and125 million persons have chronic hepatitis B &C virus (HBV& HCV) infections, respectively. This study aimed to bridge the gap between knowledge of HBV & HCV infections and theirs prevalence among pregnant women, through assessing the impact of an educational intervention on knowledge of pregnant women toward HBV & HCV infections.
Methods: The study was a quasi-experimental one, 100 pregnant women were enrolled in the study they were in third trimester. Structured interviewing sheet, laboratory investigations, educational interventions and pre & posttest formats were utilized for the study.
Results: 89% of women exposed to surgical operations versus 11% not exposed. The Knowledge of women about method of viral hepatitis B & C infections were, 63% in pretest versus 99% in posttest formats know that viral hepatitis infection could be transmitted by transfusion of infected blood or fluids. 36% in pretest versus 92% in posttest format know that viral hepatitis infection could occur during pregnancy and childbirth. 37% in pretest versus 100% in posttest format know that drug administration and abuse are important methods of transmission of viral hepatitis (B&C) infection.
Conclusion and Recommendations: Pregnant women had knowledge deficit about viral hepatitis B and C infections. The educational interventions had a positive impact on their knowledge, the findings point to the need for more programs concerned with prevention and control of HBV&HCV infections tailored to needs; these programs have to be suitable for the cultural values of the communities.

Cite this Article: Makhlouf EM, Khaled SAA, Tosson MM. Bridging the Gap between Knowledge about Viral Hepatitis Infection (B&C) and their Prevalence among Pregnant Women. Int J Hepatol Gastroenterol. 2017;3(1): 007-013.

Published: 23 June 2017

Review Article: Colon Graft Necrosis following Esophageal Reconstruction

Abdelkader Boukerrouche*

Since the first use of the colon for esophageal reconstruction by Kelling and Vulliet, the colon reconstruction became a reliable surgical option to reconstruct partially or totally the diseased esophagus. Over the time, the efficacy of colon graft has been thoroughly evaluated and definitively attested by competent surgeons. However, the selection of colon segment and completion of the esophageal anastomosis constitute the greatest challenge during esophageal reconstruction. Furthermore, the selection of an optimal colon graft should be based on the adequacy of blood supply and the length of reconstruction. The viability and function of the graft affect greatly surgical outcome and functional results. Therefore, knowledge of risk factors, diagnosis, management and prevention of colon graft necrosis is key to understand and to perform successfully an esophageal reconstructive surgery.
Keywords: Esophageal reconstruction; Colon graft; Necrosis

Cite this Article: Boukerrouche A. Colon Graft Necrosis following Esophageal Reconstruction. Int J Hepatol Gastroenterol. 2017;3(1): 001-006.

Published: 29 May 2017

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