Volume 1 Issue 1

Research Article: Some Aspects of Gene Therapy in Serious Diseases

Rafal Al Rawi* and Rakhad Alrawi

Among the most leading top 3 causes of death world wide are cancer, coronary heart disease and diabetes. Improvements in surgical, development of new treatment strategies and radio therapeutic techniques have improved outcome of many diseases. Even though, 50% of patients still die from these diseases. Advances in gene therapy have been explored as possible modality of these diseases treatments. The goal of gene therapy is to modify a gene or genetic pathway to provide therapeutic value as well as it is important to develop a method that is safe and effective for the treatment of human diseases.The objectives of this article are to provide a short overview of gene therapy for some serious diseases, discuss most recent advances in gene therapy as well as imaging techniques that are utilized to monitor patients' response to the therapies.

Cite this Article: Rawi RA, Alrawi R. Some Aspects of Gene Therapy in Serious Diseases. Open J Biotechnol Bioeng Diagn. 2017;1(1): 009-013.

Published: 08 December 2017

Research Article: Mitochondrial Encoded Targets of Breast Cancer Anti-Mitochondrial Antibodies Implications of Mitochondrial Autoimmunity for Breast Cancer Progression

M-C Maroun, LI Grossman, WD Lancaster, M Long, R Arshad, G Aboukasm, Azadeh Stark, M Burke, D Chitale, R Zarbo, C Peebles, F Fernández Madrid*

The association of auto-antibodies with the diagnosis of Breast Cancer [BC] and other cancers has been widely reported, but they have long been regarded as the expression of non-specific autoimmunity unrelated to cancer. Multiple studies have demonstrated that the majority of auto-antibodies in cancer sera target a vast group of cellular antigens called Tumor-Associated Antigens (TAAs) [1,2].

Cite this Article: Maroun MC, Grossman LI, Lancaster WD, Long M, Arshad R, et al. Mitochondrial Encoded Targets of Breast Cancer Anti-Mitochondrial Antibodies Implications of Mitochondrial Autoimmunity for Breast Cancer Progression. Open J Biotechnol Bioeng Diagn. 2017;1(1): 001-008.

Published: 29 May 2017

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