Volume 1 Issue 1
Nadine Akbar*, David A Rudko and Katrin Parmar
Magnetic Resonance Imaging (MRI) is an essential tool for Multiple Sclerosis (MS) diagnosis and treatment, understanding MS natural history and pathophysiology, and as an outcome measure in clinical trials. This review will provide descriptions of the features, pathophysiological substrates, and clinical utility of MRI measures of MS including T2-weighted, Proton Density (PD), and Fluid-Attenuated Inversion Recovery (FLAIR) hyperintense lesions, T1-weighted hypointense lesions, gadolinium-enhancing lesions, and measures of brain atrophy. Lesion presence and atrophy within both the brain and spinal cord will be described. This review will also provide a description of non-conventional MRI markers including Diffusion Tensor Imaging (DTI), functional MRI (fMRI), Magnetization Transfer Ratio (MTR) imaging, relaxometry/ Quantitative Magnetic Susceptibility (QS) mapping, and Magnetic Resonance Spectroscopy (MRS). Basic descriptions of how these measures are obtained, the pathological substrates, clinical correlates (e.g. with physical disability, cognition, fatigue, etc.) and advantages/ drawbacks of each technique will be reviewed. Conclusions will be drawn on the overall clinical utility and future directions for use of MRI in MS.
Cite this Article: Akbar N, Rudko DA, Parmar K. Magnetic Resonance Imaging of Multiple Sclerosis. Sci J Mult Scler. 2017; 1(1): 008-020.
Published: 16 November 2017
Beuy Joob* and Viroj Wiwanitkit
Zika virus infection is an emerging public health problem that becomes a concern around the world. The disease is associated with congenital anomaly and abnormal neurological clinical problems.
Cite this Article: Joob B, Wiwanitkit V. Multiple Sclerosis and Zika Virus Infection: any Clinical Interrelationship? Sci J Mult Scler. 2017; 1(1): 001-002.
Published: 15 July 2017
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