Volume 1 Issue 1

Research Article: The production of Bio-energy and its properties of Transport in the Living Systems

Pang Xiao Feng*

We here introduced the form of bio - energy in living system and eluciduted again the new theory of bio-energy transport along protein molecules in living systems based on the changes of structure and conformation of molecules arising from the energy, which is released by hydrolysis of Adenosine Triphosphate (ATP). In this theory, the Davydov's Hamiltonian and wave function of the systems are simultaneously improved and extended. A new interaction has been added into the original Hamiltonian. The original wave functions of the excitation state of single particles have been replaced by a new wave function of two-quanta quasicoherent state. In such a case, bio-energy is carried and transported by the new soliton along protein molecular chains. The soliton is formed through self - trapping of two excitons interacting amino acid residues. The exciton is generated by vibrations of amide - I (C = O stretching) arising from the energy of hydrolysis of ATP. The properties of the soliton are extensively studied by analytical method and its lifetime for a wide ranges of parameter values relevant to protein molecules is calculated using the nonlinear quantum perturbation theory. The lifetime of the new soliton at the biological temperature 300K is enough large and belongs to the order of 10-10 second ort/t0 = 700. The different properties of the new soliton are further studied. The results show that the new soliton in the new model is a better carrier of bio - energy transport and it can play an important role in biological processes. This model is a candidate of the bio-energy transport mechanism in protein molecules.

Cite this Article: Feng PX. The production of Bio-energy and its properties of Transport in the Living Systems. Sci J Biomed Eng Biomed Sci. 2017;1(1): 030-052.

Published: 09 November 2017

Short Communication: Hypothesis Formation. Is there a Connection between the Venous Fullness of the Pelvic Organs and the Brain insufficiency?

Vladimir Ermoshkin*

First of all some introductory words, taken from the manual for trouble-free operation of machines and mechanisms with hydraulic control. Problems arising from the operation of hydraulic systems are usually caused by the following factors: violation of the oil change period, irregularity in cleaning of the hydraulic system, in replacement of filter elements, in elimination of leaks, in checking of pressure, flow rate and oil level. And now let's turn our attention to the cardiovascular system and to its large circle of blood circulation, in which arterial blood is pumped instead of oil.

Cite this Article: Ermoshkin V. Hypothesis Formation. Is there a Connection between the Venous Fullness of the Pelvic Organs and the Brain insufficiency? Sci J Biomed Eng Biomed Sci. 2017;1(1): 026-029.

Published: 09 October 2017

Short Communication: Bioinformatics on Unproven Secretion Systems of Vibrio Parahaemolyticus

Gururaja P. Pazhani*, Velayutham Ravichandiran, Murugan Veerapandian and Thandavarayan Ramamurthy

Several investigations were made in recent years related to Type 3 Secretion System (T3SS) and Type 6 Secretion System (T6SS) of Vibrio parahaemolyticus. However, numerous pathogenicity islands in genomes of V. parahaemolyticus remain unexploited. Considering the presence of other secretion systems such as T1SS, T2SS, T4SS and T5SS, which are associated with the pathogenicity in other bacteria exploring the Whole Genome Sequence (WGS) data, we identified the presence of T1SS-specific Escherichia coli HlyA, and Morganella morganii Vibrio ferrin homologs in V. parahaemolyticus. The T2SS encodes tight adherence (tad) locus for bacterial adherence and production of biofilm in Actinobacillus actinomycetemcomitans. This gene locus was identified as pilin in V. parahaemolyticus. Presence of VCA0120 and csu, the pilus encoding gene homologs in the environmental V. parahaemolyticus strains supports the view that part of T4SS may be active in this Vibrio. This information should be explored further in the diseases progress using In vitro and In vivo models.

Cite this Article: Pazhani GP, Ravichandiran V, Veerapandian M, Ramamurthy T. Bioinformatics on Unproven Secretion Systems of Vibrio Parahaemolyticus. Sci J Biomed Eng Biomed Sci. 2017;1(1): 020-025.

Published: 09 October 2017

Review Article: Exploring the Potentiality of Knits for Newer Areas of Medical Applications

Gokarneshan N* and Dhatchayani U

Knits play a crucial role in the area of medical applications as recent research show. Knitted meshes have been developed from synthetic and natural materials. When used singly, they can patch soft tissues, and when used in combination, they can replace or repair damaged tissues or organs, and thereby hold promise in tissue engineering and regenerative medicine. A knit garment has been designed through integration of the knitwear technique, garment design skill, chinese acupuncture therapeutic method and Transcutaneous Electrical Nerve Stimulation(TENS) technology and has been found to be more effective than garments already incorporating TENS device in the management of body pains. Cardiac stents made of knitted and braided textile material have been developed recently. The knitted stent was found to be superior in mechanical properties and was able to fulfil the requirements better than that of metallic ones owing to better flexibility. Knits made from poly lactic acid filaments have been evaluated for suitability in urinary bladder reconstruction. Warp knit spacer fabrics have been used effectively in atrial mitral valve therapy by means of suture less technique. Weft knits from polydioxanone have been used as stents in treating intestinal stenosis as well. Shape memory weft knit single jersey structure has been developed as shape memory fabric and holds promise in the biomedical areas such as artificial tendons, artificial corneas, hernia repair, artificial bone joints, orthodontics, scaffold material and wound dressing. Knitted compression garments have proved effective in the treatment of burns and lowering of blood pressure etc.

Cite this Article: Gokarneshan N, Dhatchayani U. Exploring the Potentiality of Knits for Newer Areas of Medical Applications. Sci J Biomed Eng Biomed Sci. 2017;1(1): 007-019.

Published: 07 October 2017

Research Article: Mechanical Properties of External Polymer- Carbon Stabilizers for Bone Fixation

Maciej Ambroziak, Joanna Herman, Piotr Szatkowski* and Jan Chlopek

Time and quality of bone fracture healing depends on numerous factors, including the possibility of iso-elastic fixation whose rigidness diminishes in the course of treatment. Such a fixation has two crucial advantages. It allows axial micromovements at the fracture site, which stimulates the formation of bone callus. Moreover, it also prevents torsion and angle movements that hinder the healing process. The paper focuses on mechanical fatigue examinations and biological tests conducted on the external carbon stabilizer of a highly innovative structure. Two types of carbon composite stabilizers were tested - Carboelastofix1 and Carboelastofix2 - that may both serve as an alternative to presently used metal stabilizers, mostly steel ones, and other plate osteosynthesis systems. The examined external stabilizers comprised composite plates fixed to the damaged bone by means of metal screws. The composite carbon-epoxide resin material complies with the requirements for bone stabilizers. The fatigue tests prove that the material's rigidness facilitates micromovements within the safe range, thus supporting the bone consolidation process. Additionally, the level of stiffness may be controlled by adding or removing successive composite plates. Such a flexibility of the system promotes the possibility to retain relative iso-elasticity of the stabilizer-bone fixation during the healing process. In the conducted fatigue tests Carboelastofix2 endowed with spatial structure revealed less elasticity, which makes it applicable for neutralization and bridge plating. In comparison to the metal stabilizers, carbon composite ones display one more strength - namely their radiolucent quality, which means the bone healing process may be closely monitored by x-ray examinations. They are also aesthetically pleasing and characterised by low mass. The mechanical examinations of both types of systems and the clinical trials carried out at the Chair and Clinic of Motor Organ Orthopaedics and Traumatology in Warsaw; prove the efficiency of Carboelastofix stabilizers applied for bone fracture treatment.

Cite this Article: Ambroziak M, Herman J, Szatkowski P, Chlopek J. Mechanical Properties of External Polymer - Carbon Stabilizers for Bone Fixation. Sci J Biomed Eng Biomed Sci. 2017;1(1): 001-006.

Published: 09 August 2017

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