Volume 2 Issue 2
Research Article: Utility of FNAC in Diagnosis of Lymph Node Malignancies: An Audit from a Rural Medical College
Manupriya Sharma*, Aruna Gupta and Rashmi Kaul
Fine needle aspiration cytology (FNAC) is a simple and rapid diagnostic procedure to identify an etiology in an enlarged lymph node. The procedure is quite effective in diagnosing malignancies in superficial lymph nodes.
Aim: To evaluate the role of FNAC as a first line investigation to identify malignancies in superficial lymph nodes.
Materials and Methods: This is a retrospective review of malignant lymph node aspirates identified in superficial lymph nodes over a period of two years from June 2014 to May 2016 in the Department of Pathology, Dr. RPGMC, Tanda, Himachal Pradesh, India.
Results: A total of 1026 lymph node aspirates were identified during this period. Out of all, 188 cases (18%) were identified as malignancies in lymph nodes. The age of patients in malignant lymph node aspirates ranged from 12 years to 92 years. There were 145 males (77%) and 43 females (23%). The male to female ratio was 3.5:1. Cervical lymph node (140/188; 74%) was the main group of lymph node involved. Metastasis to lymph nodes (158 cases; 84%) was more common than primary lymphomas (30 cases; 16%). Squamous cell carcinoma (96/158; 60%) was the most common metastatic malignancy identified. Lungs (51/158; 32%) were the most common primary malignancy site. In 12% cases, the primary site was unknown and the malignancy was first diagnosed on FNAC. Among primary lymphomas, Non Hodgkin Lymphoma was seen in 67% (20/30 cases) and Hodgkin's Lymphoma in 33% (10/30 cases).
Conclusion: Present study highlights the importance of FNAC in diagnosing malignancies in superficial lymph nodes. Majority of benign etiologies can be triaged, thereby focusing attention on more sinister cases like malignancies. It also helps to diagnose malignancy in advanced stage patients. Based on the FNAC diagnosis, these cases can be managed on palliative care thereby saving the patient from excision biopsy. In many cases, FNAC proves itself as a first investigation to clinch diagnosis in occult malignancy where there is no clinical suspicion.
Cite this Article: Manupriya S, Aruna G, Kaul R. Utility of FNAC in Diagnosis of Lymph Node Malignancies: An Audit from a Rural Medical College. Int J Cancer Cell Biol Res. 2017; 2(2): 034-038.
Published: 22 November 2017
Research Article: In silico Antidiabetic Activity of Linalool Isolated From Coriandrum sativum Linn Fruit
M Padmaa Paarakh*
Background and aim: Diabetes Mellitus [DM] is a metabolic disorder characterized by disturbances in carbohydrate, protein and lipid metabolism and by complications like micro vascular (retinopathy, neuropathy and nephropathy) and macro vascular (heart attack, stroke and peripheral vascular disease) complications. Coriandrum sativum Linn has been claimed to possess antidiabetic properties in Traditional System of Medicine. This study aimed to evaluate molecular interaction of linalool in C.sativum and targeted protein related to Type 2 DM.
Material and Methods: Isolation of Linalool from the methanol extract of fruit of C.sativum was done by column chromatography. Evaluation of hypoglycemic activity through an in silico docking approach with molecular target such as glutamine: fructose- 6-phosphate amidotransferase was performed. Molecular docking study was performed with Autodock docking software.
Results: The docking studies of the ligand linalool with target protein showed that this is a good inhibitor, which docks well related to diabetes mellitus with -2.0297kJ mol-1 Van der waal energy and -5.9265 kJ mol-1 as docking energy. Hence linalool can be considered for developing into a potent anti-diabetic drug.
Conclusion: Management of diabetes is challenge to the medical treatment. This leads to increasing demand for natural products with antidiabetic activity with fewer side effects. This work establishes C.sativum extract as a potential inhibitor for diabetes. Thus enabling a possibility of this plant extract as a new alternative to existing diabetic treatment.
Cite this Article: Padmaa Paarakh M. In Silico Antidiabetic Activity of Linalool Isolated From Coriandrum Sativum Linn Fruit. Int J Cancer Cell Biol Res. 2017; 2(2): 029-033.
Published: 28 September 2017
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