Volume 2 Issue 1
Research Article: Green Tea Consumption Ameliorates Intestinal and Hepatic -Toxicity induced by Long-Term administration of Cisplatin
Sara A Khan, PhD, Shubha Priyamvada, PhD, Sheeba Khan, PhD, Md Wasim Khan, PhD and Ahad N.K.Yusufi, PhD*
Background: Cisplatin (CP) is one of the most effective anti-cancer agents but its use is limited due to renal, hepatic, and intestinal toxicity. Various strategies were made to ameliorate CP - induced damage but were not found suitable for clinical practice. Green tea (Camellia sinensis) has been used for centuries as a medicinal drink. Green Tea (GT) polyphenols have shown strong chemo preventive and chemotherapeutic effects against various pathologies including cancer, diabetes, depression, cardiovascular, and neurological disorders and renal failure. Recently we have shown that GT consumption prevents CP induced nephrotoxicity.
Aim: We now hypothesized that GT would protect against CP-induced intestinal and hepatic toxicity by virtue of its antioxidant properties.
Methods: CP was co - administered to control and GT - fed male Wistar rats over a period of 25 days. Enzymes of oxidative stress, Brush Border Membrane (BBM), and carbohydrate metabolism were analyzed.
Results: CP Suppressed Superoxide Dismutase (SOD) and catalase activities in both intestine and liver. The activity of glucose-6-phosphate dehydrogenase increased whereas that of malic enzyme decreased. However, GT given to CP rats improved the overall metabolism, enhanced antioxidant defense and energy metabolism. The BBM enzymes were differentially altered by GT.
Conclusion: In conclusion, Green Tea Ameliorates CP elicited toxicity and oxidative damage by improving antioxidant defense, tissue integrity and energy metabolism.
Cite this Article: Sara AK, Shubha P, Sheeba K, Md Wasim K, Yusufi ANK. Green Tea Consumption Ameliorates Intestinal and Hepatic -Toxicity induced by Long-Term administration of Cisplatin. Int J Drug Metab Toxicol. 2018;2(1): 001-009.
Published: 27 January 2018
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