Volume 3 Issue 4
Research Article: Non-Invasive Fibrosis Scores and Liver Stiffness Changes in Chronic Hepatitis C after Sofosbuvir-based Treatment
Hend I. Shousha*, Marwa K. Mehassab, Mai I. Mehrez, Shahira A. Afifi, Marwa Elsharkawy, Mai Hamed and Rasha A. Abdelaziz
Background: The precise evaluation of hepatic fibrosis is crucial in the management of Chronic Hepatitis C (CHC). Multiple non-invasive serological scores and devices have been used in the accurate prediction of fibrosis however; early changes in non-invasive biomarkers of liver fibrosis following antiviral therapy are widely unknown. We aim to evaluate changes of liver stiffness and 6 non-invasive serological fibrosis scores, easy to calculate particularly in poor areas, following sofosbuvir- based treatment.
Methods: This is a cohort study that included 155 CHC Egyptian patients. Transient elastography values were recorded as well as Aspartate Aminotransferase-To-Platelet Ratio Index (APRI), FIB-4, Lok score, fibrosis index, King Score and fibro Q score were calculated at baseline and 12 weeks post-treatment.
Results: There was a significant decline of aminotransferases and hemoglobin levels in all patients. There was a significant improvement in all studied fibrosis scores 12 weeks post-treatment except the fibrosis index. Liver stiffness measurements were significantly lower 12-weeks post-treatment (10 ± 8.06 vs 9.27 ± 8.51 kPa, P-value = 0.001). 145 (93.6%) patients achieved sustained virological response. There was no difference between responders and non-responders in baseline or post treatment liver stiffness or fibrosis scores values.
Conclusion: Sofosbuvir-based treatment resulted in a clinically significant improvement in parameters of liver fibrosis.
Cite this Article: Shousha HI, Mehassab MK, Mehrez MI, Afifi SA, Elsharkawy M, et al. Non-Invasive Fibrosis Scores and Liver Stiffness Changes in Chronic Hepatitis C after Sofosbuvir-based Treatment. Int J Hepatol Gastroenterol. 2017;3(4): 085-090.
Published: 27 November 2017
Image Article: Laser Spectroscopy, Laser-Induced Breakdown Spectroscopy and Laser-Induced Plasma Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation
In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of synchrotron radiation using Laser Spectroscopy, Laser-Induced Breakdown Spectroscopy (LIBS) and Laser-Induced Plasma Spectroscopy (LIPS). It is clear that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 1-3) [1-102].
Cite this Article: Heidari A. Laser Spectroscopy, Laser-Induced Breakdown Spectroscopy and Laser-Induced Plasma Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Int J Hepatol Gastroenterol. 2017;3(4): 079-084.
Published: 27 November 2017
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