Volume 1 Issue 2

Research Article: Healing of Experimental Aseptic Skin Wound under the Influence of the Wound Dressing, Containing Silver Nanoparticles

Alexander Yu. Vasil'kov1, Ruslan I. Dovnar2, Siarhei M. Smotryn2, Nikolai N. Iaskevich2 and Alexander V. Naumkin1*

A series of wound dressings, containing silver nanoparticles, based on medical gauze bandages, was obtained by the metal-vapor synthesis. Experimental laboratory rats were used to model aseptic skin wounds. The comparative dynamics of wound healing using a dressing containing silver nanoparticles and a conventional medical gauze dressing was studied. The influence of the silver-containing dressing material on the leukocyte number and blood leukogram, the main indicators of biochemical analysis of blood, was investigated. The wound dressings containing silver nanoparticles can accelerate the healing process of an experimental aseptic wound without significantly affecting the key indicators of the body homeostasis.
Keywords: Silver nanoparticles; Aseptic skin wound; Medical gauze dressing; Metal-vapor synthesis; XPS

Cite this Article: Vasil'kov AY, Dovnar RI, Smotryn SM, Iaskevich NN. Naumkin AV. Healing of Experimental Aseptic Skin Wound under the Influence of the Wound Dressing, Containing Silver Nanoparticles. Am J Nanotechnol Nanomed. 2018; 1(2): 069-077.

Published: 29 December 2018

Mini Review: Nano Spray Drying of Pharmaceuticals

Arpagaus Cordin*

Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder particles to the submicron- and nanoscale with very narrow size distributions and sample quantities in the milligram scale at high product yields. This enables the economical use of expensive active pharmaceutical ingredients and pure drugs. The present paper explains the concept of nano spray drying and discusses the influence of the main process parameters on the final powder properties like particle size, morphology, encapsulation efficiency, and drug loading. Application results of nano spray drying for the formulation and encapsulation of different drugs are reviewed. Keywords: Nano spray drying; Pharmaceuticals; Drug encapsulation; Particle size; Powder

Cite this Article: Arpagaus C. Nano Spray Drying of Pharmaceuticals. Am J Nanotechnol Nanomed. 2018; 1(2): 064-068.

Published: 24 November 2018

Research Article: Atorvastatin in PLGA-PEG Nanoparticles Derivatized with the HIV-TAT Peptide Protects Neuronal Cultures in an Oxygen-Glucose Deprivation (OGD) Model

Angel Cespedes, Maria Jose Perez, Maria Jose Gomara, Francisco Wandosell*, Isabel Haro

The development of new nanotechnology-based drug delivery systems, such as Polymer-Based Nanoparticles (NPs), is a new strategy to increase the solubility and bioavailability of many pharmaceutical compounds. Indeed, Poly(Lactic-Co-Glycolic Acid) (PLGA) is one of the most successfully used biodegradable polymers.
The purpose of the current work was to determine whether the neuroprotective efficiency of, Atorvastatin (ATV), was altered when encapsulated using ATV-loaded PLGA NPs. However, the poor aqueous solubility of ATV hinders the in vivo efficacy of this drug. We prepared a biodegradable NP complex based on PLGA with a non-ionic amphiphilic surfactant, Polyethylene Glycol (PEG). We evaluate the biological activity and neuroprotective effects of PLGA-PEG-HIV-TAT/ATV, in comparison with free ATV, using a human neuronal cell line (SH-SY5Y) and primary mouse neuronal cultures as biological models. And next we evaluate the neuroprotective effects of PLGA-PEG-HIV-TAT/ATV, in comparison with free ATV using a cellular model of brain stroke, Oxygen and Glucose Deprivation (OGD).
We first determined toxicity and efficiency of internalization and colocalization within the inner compartments of neuroblastoma cells SH-SY5Y and cortical neurons. The data showed that the NPs could cross the cell membrane, being detected in the cytoplasm as early as 4 h after administration and decreasing through 24 h. NPs did not present toxicity at the concentrations tested, with or without ATV loading. Next, we examined the ability of the PLGA-PEG-HIV-TAT/ATV polymer complex to prevent toxicity and death of SH-SY5Y cells in a model of Oxygen-Glucose Deprivation (OGD) at different concentrations. ATV-loaded NPs, increased cell viability by approximately 85-95% and had no significant cytotoxic effect. The data showed that they could be used as alternative neuroprotective strategy to deliver compounds such as statins. Thus, we propose that these NPs are promising nanosystems for the treatment of some neurological disorders, if they improve the passage of ATV across the blood-brain barrier.

Cite this Article: Cespedes A, Perez MJ, Gomara MJ, Wandosell F, Haro I. Atorvastatin in PLGA-PEG Nanoparticles Derivatized with the HIV-TAT Peptide Protects Neuronal Cultures in an Oxygen-Glucose Deprivation (OGD) Model. Am J Nanotechnol Nanomed. 2018; 1(2): 055-063.

Published: 04 November 2018

Research Article: Computational Study of Carbon, Silicon and Boron Nitride Nanotubes as Drug Delivery Vehicles for Anti-Cancer Drug Temozolomide

Farshad Shahidi1* and Seyed Majid Hashemianzadeh2

Using various nanotubes for targeted drug delivery systems as well as interactions between drug and nanotubes with diverse properties such as gender, structure, and diameter are investigated based on Density Functional Theory (DFT) for the first time. A wide assortment of weak absorption on SWCNTs and SWBNNTs, it is demonstrated that Temozolomide (TMZ) molecule tend to be physical absorption into SWSiCNTs. The geometrical structures, energetics, and electronics properties of TMZ molecule and nanotubes obtained. There is a tolerable competing amount between decreasing of diameter and curvature effect that results indicate curvature has a much more salient effect. The results obtained by the Density of State (DOS) and Molecular Orbitals (MO) indicates adsorption of the drug into nanotubes is physical.
Graphical Abstract: Drug located into nanotube, and drug distance of the nanotube interior surface is equivalent.
Keywords: Nanotube; Drug delivery; Temozolomide; Encapsulation; Drug carrier

Cite this Article: Shahidi F, Hashemianzadeh SM. Computational Study of Carbon, Silicon and Boron Nitride Nanotubes as Drug Delivery Vehicles for Anti-Cancer Drug Temozolomide. Am J Nanotechnol Nanomed. 2018; 1(2): 048-054.

Published: 04 October 2018

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