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Case Report: A Rare Case of Multiple and A Typical Plasmacytomas Locations

Lidia Mondoc, Alina Catana, Calin Cipaian, Romeo-Gabriel Mihaila*

Solitary plasmacytoma can occure in the skeleton or in soft tissues. Multiple plasmacytomas are either primary or recurrent. We present the case of a 29-year-old patient hopspitalised for headache, dizziness, fever, dysphagia, olfactive disorders, swelling and pain of the left nasal region and left maxillary sinus. The CT scan diagnosed a tumor located at the nose and pharix, to which the hystopathological and immunohystochemical examination of biopsy established the diagnosis of extramedullary plasmacytoma of the nasal cavity, and ethmoidal and left maxillary sinus. At the time, he had no skeletal lesions. The patient postponed the suggested treatment. Six months later he returned and accepted the surgical excision, followed by radiotherapy. Then, it ruled out a possible multiple myeloma. Four months later he presented new lesions: an eight cm mass on the 6th right rib, osteolithic lesions on the posterior side of the T5 vertebra, on the left 5th rib, on the sternum, and macronodular lesions measuring 8 cm on the left lobe of the liver. The liver biopsy discovered an infiltrate with CD138 positive tumour cells. A repeated bone marrow biopsy showed again a normal marrow cellularity. He was treated with chemo- and radiotherapy and zoledronic acid.The relationship between plasmacytoma and the chronic hepatitis B infection and the diabetes is discussed. A careful monitoring and patient compliance are needed to an early diagnosis of possible new pasmocytoma lesions. A possible shift to a multiple myeloma should be constantly considered.

Cite this Article: Mondoc L, Catana A, Cipaian C, Mihaila RG. A Rare Case of Multiple and A Typical Plasmacytomas Locations. Open J Oncol Hematol. 2016;1(1): 001-007.

Published: 10 November 2016

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